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All-on-4 / All-on-6
Evidence libraryDental · All-on-4 / All-on-610 papers
2 daysFixed provisional same day10 cited papers
§ Dental · 03

All-on-4 / All-on-6. What the literature actually says.

A short, honest read on full-arch immediate-load rehabilitation, what the long-term data shows, and where the residual unknowns sit. Every claim links to the paper.

01

What it is.

All-on-4 is a full-arch fixed prosthesis supported by four implants — two anterior, two posterior, the posterior pair tilted distally to engage dense cortical bone without sinus or nerve encroachment. All-on-6 uses the same geometry with two additional anterior implants for cases where bone permits and the patient prefers the load redundancy. Both protocols deliver an immediate, fixed provisional prosthesis at surgery — the patient walks out with fixed teeth that afternoon.

The protocol exists because edentulous arches that lack posterior bone height — the typical late-stage edentulous mandible or atrophic maxilla — historically required bone-graft procedures with six-month healing windows. Tilted posterior implants engage existing bone without grafting, compressing what was a year of staged surgery into a single procedural visit plus a definitive prosthesis at three to six months.

02

The technique.

An EFP-credentialed prosthodontist plans the case on CBCT with full-arch virtual surgical planning. The Maló protocol — established 1998, refined across 25 years of single-centre case data — specifies anterior implant positions roughly at the lateral incisor sites, posterior implants tilted 30°–45° distally with their emergence at the second-premolar position. This geometry distributes occlusal load across the full arch from only four fixtures.

Two daycase visits cover the work: day one is surgery — extractions where required, implant placement, immediate impression, fixed provisional in PMMA fitted before the patient leaves the suite. The provisional is in light occlusion (anterior contact only) for the osseointegration period to limit posterior cantilever load.

Day two — typically three to six months later — is the definitive prosthesis: scan-based design, milled titanium or zirconia framework, ceramic teeth, intaglio fit verified, screw-retained for retrievability. No intervening inpatient stay, no overnight admission.

03

What the outcomes data shows.

Maló et al. (2019, Clinical Implant Dentistry and Related Research) reported the longest single-centre cohort: 471 patients followed 10–18 years, 1,884 implants in immediate function, cumulative prosthesis survival 98.8% at endpoint. Implant-level survival was lower at the implant level (because individual fixture loss did not always equal prosthesis loss — the four-implant geometry tolerates one failure without prosthesis remake in many cases).

Soto-Penaloza et al. (2017, Journal of Clinical and Experimental Dentistry) systematically reviewed the All-on-4 literature beyond the Maló group and found cumulative prosthesis survival 99.8% at three years across the included independent cohorts, with implant-level survival in the 94–99% range depending on arch and bone quality.

Marginal bone loss across the published cohorts averages 1.5–2.0 mm at five years from the initial baseline, then stabilises — consistent with the wider implant literature when the prosthesis is screw-retained and hygienically accessible. Prosthetic complications (chipping, screw loosening, fracture of the provisional) are common; biological complications (peri-implantitis, implant loss) are uncommon.

04

What we still study.

The unresolved long-term question is patient-level peri-implant disease across the 15-to-20-year horizon. The Maló cohort is single-centre with strict follow-up. Independent multi-centre cohorts at the same horizon do not yet exist at adequate sample size — the protocol was popularised globally only after 2010, and 15-year multi-centre data is still being accumulated.

The other unsettled question is whether All-on-6 meaningfully outperforms All-on-4 across the long term. The biomechanical argument for redundancy is intuitive but small published cohorts have not detected a survival difference. The decision in practice rests on bone availability and patient-specific load factors — not on a survival-rate gradient.

05

The Hektor protocol.

Full-arch rehabilitation at Hektor follows the Maló All-on-4 protocol — surgery, immediate fixed provisional, screw-retained definitive prosthesis at three months — across two daycase visits. The case is led by an EFP Member prosthodontist with an audited per-surgeon volume above 200 full-arch cases. No overnight admission, no hospital ward; the recovery happens in a daycase suite with the patient discharged the same day as surgery.

06 · Who's a candidate.And who isn't
You're a candidate if
  • ·Edentulous or terminal-dentition arch (failing teeth scheduled for extraction)
  • ·Sufficient bone for tilted posterior implant engagement on CBCT (typically 5+ mm anterior, 8+ mm posterior available)
  • ·Controlled medical history (HbA1c <7% in diabetics, controlled hypertension, ASA I–II)
  • ·Treated periodontitis with stable maintenance — not active disease
  • ·Realistic acceptance of the three-month provisional phase before definitive prosthesis
  • ·Age 18+ with completed skeletal growth
  • ·Committed to lifelong hygiene maintenance and 6-monthly professional cleaning
We don't operate on
  • —Insufficient bone for tilted-implant primary stability — staged grafting needed first
  • —Active untreated periodontitis (treat-first, implant-second)
  • —Uncontrolled diabetes (HbA1c >8.5%), active immunosuppression, or recent head-and-neck radiation
  • —Heavy active smoking (>10 cigarettes / day) without cessation counselling
  • —Bisphosphonate / denosumab IV therapy without coordinated medical clearance
  • —Severe parafunction (bruxism, clenching) without protective splint compliance — the prosthesis fails before the implants do

Atrophic posterior maxilla without sufficient bone for tilted distal implants is not a no — it is a different protocol. Zygomatic implants or bilateral sinus lift with staged placement are alternatives we discuss honestly. We do not force All-on-4 geometry onto bone that cannot host it.

Bruxism with documented splint compliance is workable — survival drops 2–3 percentage points in the audit but stays within the published-cohort range. We document the conversation; we do not refuse the protocol for bruxism alone.

07

Recovery, by milestone.

9 markers
Day 0 (surgery day)Extractions where required, four implants placed, immediate fixed provisional fitted before discharge. Local anaesthesia plus IV sedation; no general anaesthesia, no overnight admission. Soft-food diet starts the same evening; ice compress externally for 24–48 hours reduces swelling.
Day 1–3Peak swelling and moderate discomfort, controlled with paracetamol + ibuprofen, supplemented with short-course opioid if needed (typically not). Bruising around the chin and submandibular area is common and resolves over 7–10 days.
Week 1Suture review at day 7–10. Soft-food diet continues — no chewing on the provisional with full force. Most patients return to office work by day 5–7.
Week 2–4Soft-tissue healing complete. Speech adapts to the provisional shape; phonetic adjustments (sibilant sounds, lip support) settle by week 4. First scheduled video review with the prosthodontist.
Month 1–3Osseointegration period. Provisional remains in light occlusion. Anterior-only contact protects the posterior tilted implants from cantilever load during integration. Soft diet remains; no biting into bread crusts, apples, or steaks.
Month 3Osseointegration assessment by clinical and radiographic check. Final impressions or digital scan for the definitive prosthesis. Patient returns to Istanbul for the second daycase visit.
Month 4Definitive screw-retained prosthesis delivered — milled titanium or zirconia framework, ceramic teeth, intaglio fit verified. Full-load chewing resumes after bite calibration.
Year 1Annual review begins. Peri-implant probing depths logged. Radiographic crestal bone level baseline established. Hygienist visit interval set to 4–6 months for the first two years.
Year 5+Long-term audit endpoint. Prosthesis-level survival logged. Screw retightening or ceramic-chip repair (the common prosthetic complications) handled chairside when needed. Implant-level loss flagged for re-prosthesis planning.
08

Compared to alternatives.

Honest takeaways
vs Conventional staged implants + grafting (sinus lift, bone augmentation)

Conventional staged protocols remain the right answer when posterior bone is genuinely inadequate for tilted implants. The trade-off is 9–12 months of staged surgery versus All-on-4's same-day fixed prosthesis. All-on-4 is not 'better' — it is appropriate for the subset of edentulous arches where tilted posterior geometry engages existing bone without grafting.PMID 28298995

vs All-on-6 (six implants instead of four)

All-on-6 adds biomechanical redundancy — if one fixture is lost, the prosthesis remains supportable without remake. The intuitive case for six over four is real; the published cohorts have not detected a meaningful survival gradient between them. The decision rests on bone availability and patient-specific load factors, not on a headline survival number.

vs Conventional full denture (removable)

A removable denture is cheaper, non-surgical, and immediate — the right answer for medically compromised patients or those unable to commit to the maintenance regime. The trade-off is continued bone resorption under the denture base, accelerating future complexity. We do not steer patients away from dentures; we tell them honestly what arch resorption looks like at year 5 and let them choose.

vs Overdenture on 2–4 implants (removable, implant-retained)

An overdenture is removable for cleaning, snaps onto 2–4 implants for retention, and costs less than All-on-4. The trade-off is the removable interface — the prosthesis comes out for hygiene, and the locator attachments need replacement every 2–4 years. Appropriate when the patient wants stability without committing to a fixed prosthesis.

vs Zygomatic implants (anchored in cheekbone)

Zygomatic implants are the answer when the maxilla is too atrophic for any conventional or tilted-implant protocol. The surgery is more invasive and the failure recovery is more complex. We do not perform zygomatic placement on-site; we refer when the CBCT shows the case is beyond All-on-4 geometry.

09 · The package, and the price.One number on the page
Hektor · All-on-4 / All-on-6€5,500–8,500 single arch · €10,500–16,000 dual arch
UK private clinic£14,000–25,000 single arch
US private clinic$24,000–40,000 single arch
EU private clinic€12,000–22,000 single arch
What the Istanbul package includes
  • ·Four implants (Straumann BLX or Nobel Biocare) + multi-unit abutments
  • ·CBCT 3D imaging + virtual surgical planning
  • ·Extractions of remaining teeth in the treated arch (where required)
  • ·Immediate fixed PMMA provisional prosthesis fitted same-day
  • ·Definitive screw-retained prosthesis at month 3–4 (titanium framework + ceramic teeth or monolithic zirconia)
  • ·Post-op medication kit (antibiotics, chlorhexidine rinse, analgesia)
  • ·Suture removal + scheduled video reviews at week 2, month 1, month 3
  • ·Translator (8 languages) + airport transfers + hotel night for both visits
  • ·10-year implant warranty + 5-year prosthesis warranty (subject to maintenance compliance)
How we calibrate the figures

Pricing is per arch. Dual-arch cases (upper + lower simultaneous) are quoted with a multi-arch package rather than 2× single-arch. UK/US/EU figures are 2025–2026 publicly published private-clinic ranges for equivalent premium implant systems and definitive prostheses, not Hektor quotes.

Our Istanbul figure includes the definitive prosthesis — many advertised low prices include only the implants and the provisional, with the definitive prosthesis invoiced separately at the second visit. We disclose the comparison transparently and do not split-quote.

Zirconia definitive prosthesis is at the upper end of the range; titanium-framework with composite teeth is at the lower end. The choice is discussed at consultation on aesthetic preference, opposing dentition, and parafunction history.

10

Common questions.

10 answered
Do I really walk out with fixed teeth the same day?+
Yes — the fixed PMMA provisional is fitted before you leave the suite on surgery day. It is in light occlusion (anterior contact only) to protect the implants during osseointegration, and it looks like teeth, not like a denture. The definitive prosthesis is delivered at month 3–4 once integration is complete.
How long do All-on-4 implants last?+
The Maló group's single-centre 10–18 year cohort reports 98.8% cumulative prosthesis survival. Implant-level survival sits slightly lower because the four-implant geometry can tolerate the loss of one fixture without remake in many cases. Beyond 15 years, the multi-centre cohort sizes are still being built.
Why only four implants? Isn't six safer?+
The biomechanical argument for six is intuitive and we do offer All-on-6 when bone permits. The published evidence has not detected a survival gradient between four and six in matched cases — the tilted posterior geometry of All-on-4 distributes load well from four fixtures alone. The decision rests on bone availability and patient-specific load factors, not on a headline number.
What is the difference between All-on-4 and All-on-6?+
All-on-4 uses four implants — two anterior, two posterior tilted distally. All-on-6 adds two more anterior implants for cases where bone permits and the patient prefers the load redundancy. The prosthesis itself is the same fixed full-arch design; the cost difference reflects the two extra fixtures and the slightly longer surgery time.
How long is the recovery?+
Most patients return to office work by day 5–7. Bruising and swelling resolve over 7–10 days. The soft-food diet continues for the full 3-month provisional phase to protect osseointegration — this is the part that requires patience, not the surgical recovery itself. Full-load chewing resumes only after the definitive prosthesis at month 3–4.
What if an implant fails?+
Early failures (within 3 months) usually mean the fixture did not osseointegrate. The four-implant geometry tolerates one early failure in many cases — we re-place at month 3–4 and proceed to the definitive prosthesis. Two or more early failures require replanning, typically with a 2–3 month healing window. The 10-year warranty covers re-placement when maintenance compliance is documented.
Will I be able to clean the prosthesis at home?+
Yes — the screw-retained design is hygienically accessible with super-floss, interdental brushes, and a water flosser. The definitive prosthesis is shaped specifically for cleansibility under the intaglio. 6-monthly professional cleaning by a hygienist who understands implant maintenance is non-negotiable; without it the long-term peri-implantitis risk rises sharply.
Does it look like a denture or like teeth?+
Like teeth — the ceramic teeth on a titanium or zirconia framework are designed to match the gingival emergence and lip support of natural dentition. The prosthesis is fixed in place; it does not come out for cleaning. Phonetics adapt over 2–4 weeks as the tongue and lips learn the new arch shape.
How many visits to Istanbul?+
Two daycase visits. Visit one is surgery + immediate provisional — 3–5 days in Istanbul including arrival and the week-1 suture review (or video review and local stitch removal). Visit two is the definitive prosthesis at month 3–4 — 2–3 days in Istanbul. Total trip time is typically 6–8 days across both visits combined.
Why is All-on-4 cheaper in Istanbul than the UK or US?+
Lower clinic overheads, lower salaries, and a high concentration of full-arch volume in Istanbul. The implant fixtures (Straumann BLX, Nobel Biocare) are the same product worldwide. The cost base is different and the per-surgeon volume drives operational efficiency.
11 · Cited papers.10 linked · last updated 2026
01
The All-on-4 treatment concept for the rehabilitation of the completely edentulous mandible: A longitudinal study with 10 to 18 years of follow-upMaló P, de Araújo Nobre M, et al. · Clinical Implant Dentistry and Related Research · 2019 · n=471 patients / 1,884 implants · PMID 30924309The longest single-centre All-on-4 cohort: 98.8% cumulative prosthesis survival across 10–18 years — the headline long-term datum.
PubMed
02
A longitudinal study of the survival of All-on-4 implants in the mandible with up to 10 years of follow-upMaló P, de Araújo Nobre M, et al. · Journal of the American Dental Association · 2011 · PMID 21357865The first 10-year mandibular cohort from the originating centre — 93.8% cumulative patient-level success, 99.2% prosthesis survival.
PubMed
03
The all-on-four treatment concept: Systematic reviewSoto-Penaloza D, Zaragozí-Alonso R, et al. · Journal of Clinical and Experimental Dentistry · 2017 · PMID 28298995Independent systematic review across multiple centres beyond the Maló group — 99.8% prosthesis survival at 3 years.
PubMed
04
Consensus statements and clinical recommendations on treatment indications, surgical procedures, prosthetic protocols and complications following All-On-4 standard treatmentPeñarrocha-Diago M, Maestre-Ferrín L, et al. · Journal of Clinical and Experimental Dentistry · 2017Multi-centre consensus on patient selection, tilted-implant angulation, immediate provisional protocol, and complication management.
DOI
05
Three-year clinical and radiographic outcomes of patients treated according to the All-on-4 concept in the daily practice: A prospective observational study on implants and prosthesis survival rates and complicationsTallarico M, et al. · Journal of Oral Science & Rehabilitation · 2018Daily-practice three-year prospective cohort — confirms that the headline survival numbers reproduce outside the originating centre.
Link
06
Peri-implant diseases and conditions: Consensus report of workgroup 4 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and ConditionsBerglundh T, Armitage G, et al. · Journal of Clinical Periodontology · 2018 · PMID 29926955Case-definition document for measuring peri-implant disease around full-arch fixtures — the framework against which long-term All-on-4 audits run.
PubMed
07
Effectiveness of Implant Therapy Analyzed in a Swedish Population: Prevalence of Peri-implantitisDerks J, Schaller D, et al. · Journal of Dental Research · 2016 · n=588 patients · PMID 26701919Population-level peri-implantitis prevalence at 9 years — the long-term complication baseline that any full-arch programme must measure against.
PubMed
08
Immediate Loading of Post-Extraction Implants: Success and Survival Rates: A Systematic Review and Meta-AnalysisLozano-Carrascal N, et al. · Applied Sciences · 2024Recent meta-analysis supporting the immediate-load mechanism that underlies All-on-4's same-day fixed-prosthesis delivery.
DOI
09
The effectiveness of immediate, early, and conventional loading of dental implants: a Cochrane systematic review of randomized controlled clinical trialsEsposito M, Grusovin MG, et al. · European Journal of Oral Implantology / Cochrane Database · 2013 · PMID 23543525Cochrane synthesis underpinning the same-day delivery model — immediate loading is non-inferior when primary stability is achieved.
PubMed
10
Immediate Loading of Implants-Supported Fixed Partial Prostheses in Posterior Regions: A Systematic ReviewVarious authors · Journal of Clinical Medicine · 2025Confirms posterior-region immediate-load survival 86–100% — relevant to the All-on-4 distal tilted fixture under occlusal load.
DOI
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